M-Audio Radium 49 is an "end of line" product, meaning official driver support has ceased for recent macOS versions. If you are using a modern Mac (macOS Catalina, Big Sur, Monterey, Ventura, or Sonoma), it will likely not work via a direct USB connection because it is not class-compliant and requires legacy drivers. Apple Discussions Compatibility Status Officially Supported: Up to macOS 10.8.5 (Mountain Lion). Last Known Working (with Drivers): Some users have successfully used the MIDI USB Driver v3.5.3 on macOS Mojave (10.14) or Yosemite (10.10.3). Incompatible:
Most DAWs allow MIDI Learn. Map the Radium’s knobs/sliders manually to parameters.
Limitation: The device sends raw MIDI CCs; without the driver, the mapping is not persistent across all software. m-audio radium 49 driver mac
The Radium 49 is not "class-compliant," meaning it requires a specific driver to communicate via USB. Official support effectively ended after OS X 10.8 Mountain Lion. M-Audio Radium 49 is an "end of line"
Your Mac will "see" the interface, which is class-compliant, and the Radium 49 will work perfectly with Logic, Ableton, or GarageBand. Solution 2: The "Midiman" Legacy Driver Hack If the DAW doesn’t receive notes, open a
having trouble with a radium 49 key stati… - Apple Community