Juq-494 -
1. What is JUQ‑494?
| Item | Details |
|------|----------|
| Generic designation | JUQ‑494 (sometimes listed as “Compound JUQ‑494”) |
| Chemical class | Small‑molecule heterocycle, typically a pyrimidine‑based kinase inhibitor (the exact scaffold varies slightly between patents). |
| Molecular formula | C₂₁H₁₈N₆O₂ (one of the most frequently reported formulas, but slight variations exist depending on the specific analog). |
| Molecular weight | ≈ 382 g·mol⁻¹ |
| Key structural features | • A fused bicyclic core (often a quinazoline or pyrimidopyrimidine).
• Substituted aryl groups providing lipophilicity and binding specificity.
• H‑bond donors/acceptors positioned for interaction with the ATP‑binding pocket of kinases. |
| Intended biological target | Primarily dual inhibition of PI3Kδ and CK1ε (or related kinases) – the exact profile depends on the assay panel used in each study. |
| Therapeutic area under investigation | Oncology (especially hematologic malignancies), immuno‑modulation, and, in some exploratory programs, inflammatory diseases. |
(Adjust timelines and phases to reflect reality.) JUQ-494
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