Getting Codebreaker 10.1 to run as an ISO or ELF file on your PS2 is a common way to use cheats with modern softmods like Free McBoot (FMCB) and Open PS2 Loader (OPL).  Quick Setup Guide for PS2 Hardware 

Evaluation: Codebreaker 10.1 ISO PS2L

Overview

Developed by Pelican Accessories, Codebreaker is a cheat device that allows players to inject "raw codes" into their favorite PS2 titles. Version 10.1 is particularly famous because it features an updated code list supporting over 2,000 games across both PAL and NTSC regions. Setting Up Codebreaker on Modern Emulators (PCSX2)

Launch: Return to the Codebreaker menu and select "Start Game" to sideload the cheats into the game. 2. On a Modded PS2 Console (FMCB/OPL)

How to Use Codebreaker 10.1 ISO on Different Setups

1. On Original PS2 Hardware (Using a Burned Disc)

• Requirements: A PS2 with a modchip, FreeDVDBoot exploit, or MechaPwn.
• Steps:

  Select Cheats: Once Codebreaker loads, go to the cheat menu (the gas mask or gun icon), select your game and the desired cheats, then press Start. Boot the Game:

  Modded Consoles: If your PS2 has Free McBoot installed, you can launch the Codebreaker program from a USB drive or the memory card itself.